- S.F. Express
- Sagawa Express
- Saia
- Sameday Courier
- Saric
- Satellite
- Saturn Freight Systems
- Say Cargo Express
- Scan Global Logistics
- Schenker
- Schneider
- Schumacher Cargo Logistics
- SCM
- SCS Express
- SDA
- Seabourne
- SEKO Worldwide
- SendFromChina
- Service By Air
- Seur
- SH-CH Express
- Shaffer Trucking
- ShipCanada
- Skydart Express
- SkyNet Worldwide
- SMSA Express
- SMT
- SOS Global Express
- Southeastern Freight
- Sovereign Speed
- Space Courier
- Spee-Dee
- SpeedPAK
- Speedy Transport
- SSC Consolidation
- Standard Forwarding
- Star Track Express
- STAT Logistics
- Sterling Transportation
- Stevens Global Logistics
- Storm Logistics
- Suntika Courier
- SunYou Logistics
- SuperVan is now Hercules
- Sutton Transport
- Swift Transportation